We’re Making Progress!


MRF funding has supported research that…

  • Identified new chemical compounds and therapeutic targets which could provide leads for future drug development.
  • Discovered that female sufferers of migraine with aura are at increased risk of stroke in later life.
  • Revealed that opiates, which are sometimes used to treat migraine, can cause changes in the brain that last long after usage stops.
  • Established a migraine-specific DNA library and searchable electronic database for use in future research.
  • Identified five genes that are involved in the link between migraine and cardiovascular disease, particularly stroke.
  • Identified a potential mechanism underlying opioid-induced medication overuse headaches, providing a novel target for drug development.
  • Found that brief behavioral interventions, especially cognitive behavioral therapy, may reduce headache frequency and anxiety in children.
  • Showed that prolonged frequent use of triptan medication, intended to relieve headaches, may in fact induce headaches.
  • Demonstrated that there is more to migraine than genetics. While studying identical twins, three migraine variants were found in the migraine twin that were not present in the healthy twin.
  • Showed that stress causes physiological changes in the nervous system that appear to facilitate a migraine attack.
  • Uncovered startling deficits in the treatment of childhood migraine, notably treatment contrary to care guidelines, the over-prescribing of opioids, and significant under-treatment.
  • Discovered that high levels of serotonin may be an accurate migraine biomarker.
  • Showed that estrogen plays a role in migraine.
  • Identified 19 new small molecule compounds capable of selectively inhibiting the channel that causes familial hemiplegic migraine.
  • Found that a high sensitivity to external stimuli predicts the effectiveness of amitriptyline in preventing migraine, opening the door to a more personalized approach to treatment.
  • Revealed the potential of immunotherapy as a migraine treatment.
  • Discovered ground-breaking information about BDNF, a protein that could cause pain hypersensitivity in migraine.
  • Demonstrated the promise of a brief behavioral sleep intervention for migraine patients, suggesting that directly treating co-occurring insomnia may improve migraine itself.
  • Found that melatonin may be a promising and safe treatment for decreasing migraine frequency in adolescents.

There's still a lot to learn. Learn how you can help us.

Read more about the research we've funded.