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We are at the threshold of an explosion in the understanding, diagnosis, and treatment of migraine, and with the help of MRF, more answers will soon be found.
- Joel Saper, MD, Research Advisory Board Chair
David Borsook, MD, PhD

2008 MRF Research Grantee

Grantee:
David Borsook, MD, PhD
Institution:
Harvard Medical School, Boston, MA
Study Title:
Mapping Functional Brain Circuits in a Rodent Model of Central Sensitization
Study Details:
Using functional MRI to measure changes in brain circuits before and after central sensitization.

FINAL REPORT: Mapping Functional Brain Circuits in a Rodent Migraine Model of Central Sensitization

Summary

Based on our studies of imaging the trigeminal nerve (that provides sensation to the head and face) we have developed an animal model to study migraine with techniques that allow us to measure brain function (functional neuroimaging).

Hypothesis vs. Findings

The research findings supported the original hypotheses. Specifically, we could demonstrate that functional (brain) activation in brain regions shown by our group of migraine patients, are similar in this model. Furthermore, these results also replicate data obtained in neurophysiological results.

Unanswered questions

The research did not allow us to gain insights into chronic brain changes in the rat model.