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We are at the threshold of an explosion in the understanding, diagnosis, and treatment of migraine, and with the help of MRF, more answers will soon be found.
- Joel Saper, MD, Research Advisory Board Chair

a

abdominal migraine –

A variant or precursor of migraine that mostly affects children and involves moderate to severe abdominal pain and vomiting, with little or no head pain.

abortive medication –

A medication taken at the first sign of a migraine attack to stop the symptoms.

acute treatment –

A migraine therapy used to stop an attack when it begins.

allodynia –

Pain due to a stimulus that does not normally provoke pain.

aura –

A warning sign that a migraine is about to begin usually involving visual disturbances, such as flashing lights, zigzag lines, blurred vision, along with numbness or trouble speaking.

b

basilar-type migraine –

A form of migraine occurring primarily in young women that is felt on both sides at the back of the head. Symptoms may include double vision or loss of vision, numbness, dizziness and loss of balance, difficulty speaking, and fainting.

benign paroxysmal vertigo –

A variant or precursor of migraine that involves recurrent attacks of severe vertigo that resolve spontaneously.

biomarker –

objective indications of a medical state that can be observed from outside the patient and can be measured accurately

c

cephalgia (cephalalgia) –

A medical term for head pain or headache.

cervicogenic headache –

A type of headache caused by referred pain from a source in the upper cervical spine.

chronic migraine –

A form of migraine that occurs 15 or more days a month over a 3-month period.

cluster headache –

A type of primary headache with sudden, severe head pain that occurs in a closely grouped pattern several times a day and at the same time over a period of weeks.

comorbid –

The simultaneous presence of one or more usually independent disorders or diseases in a patient (like migraine and anxiety).

complimentary treatment –

A non-drug therapy used mainly for prevention, such as biofeedback, relaxation techniques, acupuncture, exercise, and lifestyle changes.

cortical spreading depression (CSD) –

A wave of increased brain activity that slowly spreads from the back toward the front of the brain’s surface and is thought to be the basis for migraine aura.

CT scan –

A diagnostic image that uses X-rays and computer technology to produce two-dimensional images of organs, bones, and tissues.

cyclical vomiting syndrome –

A variant or precursor of migraine that mostly affects children and involves recurrent episodes of intense, unexplained attacks of nausea and vomiting.

d

diagnosis of exclusion –

A diagnosis reached by a process of elimination, as there is not a test or biomarker to show its presence.

e

episodic migraine –

A form of migraine that occurs occasionally (less than 15 days per month over a 3 month period).

g

genome –

The genetic material of an organism encoded in DNA or RNA.

genotype –

An individual’s collection of genes.

h

hemicrania continua –

A one-sided headache that is chronic or continuous and responds to indomethacin treatment.

hemiplegic migraine –

A rare form of migraine that causes temporary paralysis on one side of the body often accompanied by vertigo, a stabbing sensation, and problems seeing, speaking, and swallowing.

m

medication overuse headache (rebound headache) –

A type of headache caused by the overuse of pain medications, including over-the-counter drugs. While the medication may help relieve the headaches temporarily, over time the headaches worsen and occur more frequently, creating a vicious cycle of medication use and head pain.

menstrual migraine –

A form of migraine that affects women around the time of their period.

migraine –

A type of primary headache that can last up to 3 days with moderate to severe throbbing pain, often accompanied by nausea, vomiting, sensitivity to light and sound, and fatigue.

migraine equivalents (migraine variants) –

Migraines that present with symptoms other than head pain.

migraine with aura –

A migraine that begins with a visual disturbance that appears 10-60 minutes before the head pain.

migraine without aura –

A migraine that begins with the head pain and not a visual disturbance.

mri scan –

A diagnostic image that uses a magnetic field and radio waves to create 3D images of the organs and tissues.

n

new daily persistent headache –

A type of headache characterized by its quick onset, lack of headache history, and persistence on a daily basis for at least 3 months.

o

off label –

When a medication is prescribed for a condition that’s not included in the FDA approval.

opioid –

A synthetic narcotic resembling the naturally occurring opiate, that acts as a pain reliever.

p

pathophysiology –

The functional changes that accompany a disease or syndrome

phenotype –

The observable traits or characteristics of an individual resulting from the expression of genes and environmental influences.

phonophobia –

Extreme sensitivity to sound resulting from a migraine.

photophobia –

Extreme sensitivity to light resulting from a migraine.

polymorphism –

Natural variations in a gene, DNA sequence, or chromosome that have no adverse effects on the individual and occur with high frequency in the general population.

postdrome –

The last phase of a migraine, following the head pain.

premonitory phase (prodrome) –

The first phase of a migraine, occurring 1-2 days before the attack.

preventive treatment –

A migraine therapy used to reduce the number of attacks, lessen the intensity of pain, and prevent the onset of future migraines.

primary headache –

A headache that is not caused by another medical condition, like migraine, tension-type headache, and cluster headache.

prodrome (premonitory phase) –

The first phase of a migraine, occurring 1-2 days before the attack.

r

rebound headache (medication overuse headache) –

A type of headache caused by the overuse of pain medication, including over-the-counter drugs. While the medication may help relieve the headaches temporarily, over time the headaches worsen and occur more frequently, creating a cycle of medication use and head pain.

retinal migraine (ocular migraine, ophthalmic migraine) –

A form of migraine characterized by short attacks of fully reversible lost or impaired vision in one eye.

s

secondary headaches –

A headache that is caused by an underlying condition or disease, such as headaches resulting from concussions and infections

status migrainosus –

A severe form of persistent migraine lasting more than 72 hours.

t

tension-type headache –

A common primary headache characterized by a squeezing feeling around the forehead. Tension headaches are not migraines.

trigger –

Anything that brings on a migraine attack (like weather, a strong odor or light), either alone or in combination with other risk factors.

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